abstract：:Prostate specific antigen (PSA) is a serine protease that is exclusively produced in the prostate, and its detection is the only laboratory test available for screening men for prostate cancer (PC). The interpretation of the assay is difficult since it is specific for prostate tissue and cellular growth, but not for P...

journal_title：IUBMB life

authors： Mener DJ

更新日期：2010-08-01 00:00:00

abstract：:Triclosan, a well-known inhibitor of Enoyl Acyl Carrier Protein Reductase (ENR) from several pathogenic organisms, is a promising lead compound to design effective drugs. We have solved the X-ray crystal structures of Plasmodium falciparum ENR in complex with triclosan variants having different substituted and unsubst...

journal_title：IUBMB life

authors： Maity K,Bhargav SP,Sankaran B,Surolia N,Surolia A,Suguna K

更新日期：2010-06-01 00:00:00

abstract：:Bladder carcinoma is an important worldwide health problem. Both cystoscopy and urine cytology used in detecting bladder cancer suffer from drawbacks where cystoscopy is an invasive method and urine cytology shows low sensitivity in low-grade tumors. This study validates easier and less time-consuming techniques for t...

journal_title：IUBMB life

authors： Eissa S,Shabayek MI,Ismail MF,El-Allawy RM,Hamdy MA

更新日期：2010-05-01 00:00:00

abstract：:Recently, three independent laboratories reported the generation of induced pluripotent stem cells (iPSCs) from pig (Sus scrofa). This finding sums to the growing list of species (mouse, human, monkey, and rat, in this order) for which successful reprogramming using exogenous factors has been achieved, and multiple ot...

journal_title：IUBMB life

authors： Esteban MA,Peng M,Deli Z,Cai J,Yang J,Xu J,Lai L,Pei D

更新日期：2010-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the presence of senile plaques and neurofibrillary tangles in the brain. The beta-amyloid peptide (Abeta) is the primary constituent of the senile plaques, and has been proposed to be a key contributor to the neurodegeneration observed in AD. The molecular mechanisms underl...

journal_title：IUBMB life

authors： Gong X,Lu X,Zhan L,Sui H,Qi X,Ji Z,Niu X,Liu L

更新日期：2010-03-01 00:00:00

abstract：:Upregulation of haptoglobin (Hp) expression in the rat during the acute phase (AP) response is the result of synergistic effects of IL-6-, IL-1beta-, and corticosterone-activated signaling pathways. IL-6 signaling terminates in cis-trans interactions of the Hp gene hormone-responsive element (HRE) with transcription f...

journal_title：IUBMB life

authors： Arambasić J,Poznanović G,Ivanović-Matić S,Bogojević D,Mihailović M,Uskoković A,Grigorov I

更新日期：2010-03-01 00:00:00

abstract：:For 8 years, it was not understood why certain genes of plant mitochondria contain CGG (arginine) codons at positions where tryptophan codons (UGG) are present in the corresponding genes of nonplant species. Identification and sequencing of a tRNA(Trp) gene showed that it is not able to decode the CGG codon. Analysis ...

journal_title：IUBMB life

authors： Grienenberger JM

更新日期：2009-12-01 00:00:00

abstract：:In most organisms, productive utilization of galactose requires the highly conserved Leloir pathway of galactose metabolism. Yet, if this metabolic pathway is perturbed due to congenital deficiencies of the three associated enzymes, or an overwhelming presence of galactose, this monosaccharide which is abundantly pres...

journal_title：IUBMB life

authors： Lai K,Elsas LJ,Wierenga KJ

更新日期：2009-11-01 00:00:00

abstract：:The ATP-sensitive potassium (K(ATP)) channel is expressed in most excitable tissues and plays a critical role in numerous physiological processes by coupling intracellular energetics to electrical activity. The channel is comprised of four Kir6.x subunits associated with four regulatory sulfonylurea receptors (SUR). I...

journal_title：IUBMB life

authors： Akrouh A,Halcomb SE,Nichols CG,Sala-Rabanal M

更新日期：2009-10-01 00:00:00

abstract：:Unique opportunities are provided by phylogenetically closely related organisms thriving in stably cold, or temperate milieus to study adaptive modifications of structurally homologous molecules. These modifications are of keen interest in basic science as well as in biotechnology. This review highlights structural an...

journal_title：IUBMB life

authors： Alimenti C,Vallesi A,Pedrini B,Wüthrich K,Luporini P

更新日期：2009-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) is an enveloped positive-strand RNA virus of the Flaviviridae family. It has a genome of about 9,600 nucleotides encoding a large polyprotein (about 3,000 amino acids) that is processed by cellular and viral proteases into at least 10 structural and nonstructural viral proteins. A novel HCV pro...

journal_title：IUBMB life

authors： Vassilaki N,Mavromara P

更新日期：2009-07-01 00:00:00

abstract：:The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different int...

journal_title：IUBMB life

authors： Morgan MR,Byron A,Humphries MJ,Bass MD

更新日期：2009-07-01 00:00:00

abstract：:The amino acids glutamate and gamma-aminobutyric acid (GABA) have primarily been characterized as the most prevalent excitatory and inhibitory, respectively, neurotransmitters in the vertebrate central nervous system. However, the role of these signaling molecules extends far beyond the synapse. GABA, glutamate, and t...

journal_title：IUBMB life

authors： Dave KA,Bordey A

更新日期：2009-05-01 00:00:00

abstract：:Apolipoprotein E (apoE) is a major constituent of lipoproteins mediating peripheral uptake of lipids including the lipid-soluble vitamin alpha-tocopherol (alpha-toc). In a recent study, we observed significant lower alpha-toc concentrations in the lung of apoE4 compared with apoE3 transgenic mice. In this study, we de...

journal_title：IUBMB life

authors： Huebbe P,Jofre-Monseny L,Rimbach G

更新日期：2009-04-01 00:00:00

abstract：:In the present study we demonstrated Jurkat leukemia cell lines of TIB152 and TIB153 with different sensitivities to recombinant soluble TRAIL cytotoxicity. TRAIL receptor death receptor 5 (DR5) was constitutively localized in the rafts in both cell lines. FADD, caspase-8, and PI3K-p85 subunit were recruited into DR5 ...

journal_title：IUBMB life

authors： Min Y,Shi J,Zhang Y,Liu S,Liu Y,Zheng D

更新日期：2009-03-01 00:00:00

abstract：:Worldwide, one of the most prevalent forms of chronic disease is alcoholic fatty liver, which may progress to more severe forms of liver injury including steatohepatitis, fibrosis, and cirrhosis. The molecular mechanisms by which ethanol consumption causes accumulation of hepatic lipid are multiple and complex. Chroni...

journal_title：IUBMB life

authors： Rogers CQ,Ajmo JM,You M

更新日期：2008-12-01 00:00:00

abstract：:The generation of free radicals and the resulting oxidative modification of cell structures are omnipresent in mammalian cells. This includes the permanent oxidation of proteins leading to the disruption of the protein structure and an impaired functionality. In consequence, these oxidized proteins have to be removed ...

journal_title：IUBMB life

authors： Jung T,Grune T

更新日期：2008-11-01 00:00:00

abstract：:For more than a century, the metabolic role of lactate has intrigued physiologists and biochemists. Yet, for the first half of the last century lactate had been designated as a waste product, and assigned no additional significance besides its controversial role in muscle fatigue. The decline of the lactate hypothesis...

journal_title：IUBMB life

authors： Sola-Penna M

更新日期：2008-09-01 00:00:00

abstract：:Implantation is a complex developmental event that is initiated by recognition and adhesion of the embryo to the endometrial epithelium. sLeX is an oligosaccharide antigen acting as the ligand of L-selectin, and is stage-specifically expressed in the endometrial epithelium. The adhesion system mediated by L-selectin a...

journal_title：IUBMB life

authors： Liu S,Zhang Y,Liu Y,Qin H,Wang X,Yan Q

更新日期：2008-07-01 00:00:00

abstract：:High throughput microarrays were initially developed to analyse the expression of many RNA transcripts in parallel. The technology has since been adapted to a variety of applications, one of which is the analysis of the genome to study DNA dosage and sequence content. Advances in microarray fabrication and completion ...

journal_title：IUBMB life

authors： Waddell N

更新日期：2008-07-01 00:00:00

abstract：:The mammalian antizyme (AZ) promotes ubiqutin-independent degradation of ornithine decarboxylase, a key enzyme in polyamine biosynthesis. This study shows that AZ suppression in human lung carcinoma A549 cells caused growth defects and death, but made the cells resistant to DNA damaging agents such as gamma-radiation ...

journal_title：IUBMB life

authors： Kim JS,Kim TL,Cho EW,Paik SG,Chung HW,Kim IG

更新日期：2008-06-01 00:00:00

abstract：:Mitochondria play a key role in death signaling. The intermembrane space of these organelles contains a number of proteins which promote cell death once they are redistributed to the cytosol. The formation of pores in the outer membrane of mitochondria defines a gateway through which the apoptogenic proteins pass duri...

journal_title：IUBMB life

authors： Smith DJ,Ng H,Kluck RM,Nagley P

更新日期：2008-06-01 00:00:00

abstract：:We propose a new hypothesis for the molecular mechanism by which neuroglobin exerts its protective effect in hypoxia-induced cell death. Our recent observation of a very rapid electron-transfer reaction between ferrous neuroglobin and ferric cytochrome c is central to this hypothesis. In contrast to previously suggest...

journal_title：IUBMB life

authors： Fago A,Mathews AJ,Brittain T

更新日期：2008-06-01 00:00:00

abstract：:The cancer microenvironment and the interactions between cancer and surrounding tissue cells are thought to play a pivotal role in tumor development and progression. Glycosaminoglycans (GAGs)/proteoglycans (PGs) are major constituents of the extracellular matrix, the composition of which may affect various cellular fu...

journal_title：IUBMB life

authors： Chatzinikolaou G,Nikitovic D,Asimakopoulou A,Tsatsakis A,Karamanos NK,Tzanakakis GN

更新日期：2008-05-01 00:00:00

abstract：:Transfected human apoptosis signal-regulating kinase 1 (ASK1) produces a 150 kDa protein. However, we have detected endogenous ASK1 predominantly as 39 and 50 kDa C-terminal and 75 and 110 kDa N-terminal fragments in a panel of nontransfected cancer cell lines and HUVEC endothelial cells. This suggests that in nonapop...

journal_title：IUBMB life

authors： Stordal B,Davey R

更新日期：2008-03-01 00:00:00

abstract：:Tetrameric haemoglobins display a cooperative ligand binding behaviour, which has been attributed to the functional interrelationship between multiple ligand binding sites. The quantitative description of this feature was initially carried out with a phenomenological approach, which was limited to the functional effec...

journal_title：IUBMB life

authors： Ciaccio C,Coletta A,De Sanctis G,Marini S,Coletta M

更新日期：2008-02-01 00:00:00

abstract：:In the Antarctic, fishes of dominant suborder Notothenioidei have evolved in a unique thermal scenario. Phylogenetically related taxa of the suborder live in a wide range of latitudes, in Antarctic, sub-Antarctic and temperate oceans. Consequently, they offer a remarkable opportunity to study the physiological and bio...

journal_title：IUBMB life

authors： Verde C,Giordano D,di Prisco G

更新日期：2008-01-01 00:00:00

abstract：:Sirolimus(SRL, Rapamune(â), rapamycin) is a highly specific inhibitor of mammalian target of rapamycin (mTOR). Sirolimus exerts its biological activity by inhibiting the serine-threonine kinase mammalian target of rapamycin (mTOR), which regulates important cellular processes such as control of cell cycle, cell size, ...

journal_title：IUBMB life

authors： Wang Y,Zhao Q,Ma S,Yang F,Gong Y,Ke C

更新日期：2007-11-01 00:00:00

abstract：:The pathways for ligand entry and exit in myoglobin have now been well established by a wide variety of experimental results, including pico- to nano- to microsecond transient absorbance measurements and time-resolved X-ray crystallographic measurements. Trp insertions have been used to block, one at a time, the three...

journal_title：IUBMB life

authors： Olson JS,Soman J,Phillips GN Jr

更新日期：2007-08-01 00:00:00

abstract：:The conformational stability of the homotetrameric Plasmodium falciparum beta-ketoacyl-ACP reductase (FabG) was determined by guanidinium chloride-induced isothermal and thermal denaturation. The reversible unfolding transitions were monitored by intrinsic fluorescence, circular dichroism (CD) spectroscopy and by meas...

journal_title：IUBMB life

authors： Karmodiya K,Sajad S,Sinha S,Maity K,Suguna K,Surolia N

更新日期：2007-07-01 00:00:00

abstract：:The aggressive biological behavior of invasive and metastatic cancer is considered to be the most insidious and life-threatening aspect for breast cancer patients. It is mostly the result of changes in many molecular characteristics of tumor cells, including alterations in gene expression and the balance of proteolyti...

journal_title：IUBMB life

authors： Swellam M,Arab LR,Bushnak HA

更新日期：2007-06-01 00:00:00

abstract：:The reaction between nitric oxide ((.)NO) and oxygen yields reactive species capable of oxidizing and nitrosating proteins, as well as deaminating DNA bases. Although this reaction is considered too slow to be biologically relevant, it has been shown that membranes, lipoproteins, mitochondria and possibly proteins can...

journal_title：IUBMB life

authors： Möller MN,Li Q,Lancaster JR Jr,Denicola A

更新日期：2007-04-01 00:00:00

abstract：:Epidemiological evidence demonstrates that diets rich in fruit and vegetables promote health, and attenuate, or delay, the onset of various diseases, including cardiovascular disease, diabetes, certain cancers, and several other age-related degenerative disorders. The chemical components and the physiological and mole...

journal_title：IUBMB life

authors： Fraga CG

更新日期：2007-04-01 00:00:00

abstract：:This study examined whether cell cycle regulatory proteins, such as cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors, regulate type II collagen expression and mediate interlukin-1 (IL-1beta)-induced suppression of type II collagen expression in articular chondrocytes. IL-1beta inhibited type II collagen ex...

journal_title：IUBMB life

authors： Hwang SG,Song SM,Kim JR,Park CS,Song WK,Chun JS

更新日期：2007-02-01 00:00:00

abstract：:Nuclear receptors (NRs) comprise a large family of proteins essential to manipulate various aspects of human biology. The class III of the NR family includes steroid hormone receptors (SHRs) involved in embryonic development, maintenance of differentiated cellular phenotypes, metabolism, and cell death. Dysfunction of...

journal_title：IUBMB life

authors： Marino M,Ascenzi P

更新日期：2006-12-01 00:00:00

abstract：:Recent advances in the developmental biology, genetics and cell biology of the inner ear are guiding research to novel therapeutic modalities - a market currently estimated to be at least US Dollars 10 billion. This article highlights prospects to manipulate the mammalian hearing organ with gene and stem cell delivery...

journal_title：IUBMB life

authors： Tang LS,Montemayor C,Pereira FA

更新日期：2006-09-01 00:00:00

abstract：:Interferon regulatory factors (IRFs) were originally discovered in the context of type I interferon (IFN-alpha/beta) gene induction, and subsequent studies on these transcription factors have revealed their remarkable functional diversity in regulating immune systems. Indeed, the critical involvement of IRF members in...

journal_title：IUBMB life

authors： Honda K,Taniguchi T

更新日期：2006-05-01 00:00:00

abstract：:This paper reviews our studies that have addressed the molecular mechanisms underlying the biosynthesis and reception of extracellular signaling molecules and integrative mechanisms of extracellular-intracellular signaling transmission in biological systems. We introduced recombinant DNA technology into the neuroendoc...

journal_title：IUBMB life

authors： Nakanishi S

更新日期：2006-05-01 00:00:00

abstract：:Release of arachidonic acid from membrane glycerophospholipids by cytosolic phospholipase A2 (cPLA2) is a key step in the generation of platelet-activating factor (PAF), recognized as the most proximal mediator of inflammatory events triggered by bacterial infection. Here, we report on the role of cPLA2 in the disturb...

journal_title：IUBMB life

authors： Slomiany BL,Slomiany A

更新日期：2006-04-01 00:00:00

abstract：:Fructose 2,6-bisphosphate is a potent metabolic regulator in eukaryotic organisms; it affects the activity of key enzymes of the glycolytic and gluconeogenic pathways. The enzymes responsible for its synthesis and hydrolysis, 6-phosphofructo-2-kinase (PFK-2) and fructose-2,6-bisphosphatase (FBPase-2) are present in re...

journal_title：IUBMB life

authors： Michels PA,Rigden DJ

更新日期：2006-03-01 00:00:00